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Book a consultationHeritage · cascade testing for families
A focused test for a specific, already-known variant, so blood relatives can be checked precisely for that one change.
01For one already-known variant
When one family member is found to carry an inherited cancer-risk variant, their blood relatives can be tested precisely for that one change.
One finding can protect many.
Cascade testing lets relatives learn whether they carry it. Those who do can start earlier screening or prevention. Those who do not can be reassured. It is one of the highest-impact things a family can do after a variant is found.
02
Someone in the family is found to carry it.
With their own consent and counselling.
We check precisely for that one variant. ₹35,000 per member.
Carriers get a prevention plan. Non-carriers get clarity.
A family tree with cascade testing spreading through it
03
Every relative makes their own informed choice, supported by KPCIRC genetic counselling. Testing is never imposed, and results are always delivered with support.
Being clear about our limits
| Term | What it means |
|---|---|
| Germline | An inherited change, present from birth and passable to children. |
| Somatic | A change that arises in the tumour during life. Not inherited. |
| Pathogenic variant | A change known to be disease-causing. Here, one that raises cancer risk. |
| VUS | Variant of uncertain significance, a change whose meaning is not yet clear. |
| Penetrance | How likely a carrier is to actually develop the cancer. |
| Cascade testing | Testing blood relatives for a known family variant. |
Heritage Adhoc is a genomic (DNA-based) test for use by qualified healthcare professionals. It supports clinical judgement, it does not replace it, and it must be read alongside your full clinical history and applicable guidelines.
Regulatory status (India). Registration of our genomic tests as in-vitro diagnostic (IVD) medical devices with CDSCO is in progress, with the IVD class pending. Sequencing and variant calling are done by an accredited laboratory partner (CAP-accredited, ISO 15189) following ACMG/AMP/ASCO/CAP guidelines and a CE-IVD certified variant database. The OnKommon interpretation engine is provided for research and decision-support use. Marketing follows the Drugs and Magic Remedies (Objectionable Advertisements) Act, 1954.
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