In exclusive clinical partnership with KPCIRC
OnKommon

Heritage · cascade testing for families

Heritage Adhoc

A focused test for a specific, already-known variant, so blood relatives can be checked precisely for that one change.

01For one already-known variant

Focused cascade testing

When one family member is found to carry an inherited cancer-risk variant, their blood relatives can be tested precisely for that one change.

One finding can protect many.

Cascade testing lets relatives learn whether they carry it. Those who do can start earlier screening or prevention. Those who do not can be reassured. It is one of the highest-impact things a family can do after a variant is found.

02

How it works

  1. Step 1A variant is identified

    Someone in the family is found to carry it.

  2. Step 2Relatives are offered testing

    With their own consent and counselling.

  3. Step 3A focused test

    We check precisely for that one variant. ₹35,000 per member.

  4. Step 4A plan for each person

    Carriers get a prevention plan. Non-carriers get clarity.

Diagram placeholder

A family tree with cascade testing spreading through it

What goes here: Clean family-tree diagram. One index case marked as a carrier, then arrows showing testing offered outward to siblings, children, cousins. Use colour to mark carriers, non-carriers and untested, and add a shape or label as well so it is readable without relying on colour alone.

03

Consent and counselling

Every relative makes their own informed choice, supported by KPCIRC genetic counselling. Testing is never imposed, and results are always delivered with support.

Being clear about our limits

What we do and do not do

What we DO

  • Assess inherited cancer risk for you
  • Enable cascade testing to protect blood relatives
  • Include KPCIRC genetic counselling before and after
  • Flag inherited changes that can shape treatment

What we DON’T do

  • Diagnose cancer or read the tumour
  • Predict with certainty that a cancer will occur
  • Test relatives without their own consent and counselling
  • Replace clinical screening or specialist follow-up
Plain-language glossary (6 terms)
TermWhat it means
GermlineAn inherited change, present from birth and passable to children.
SomaticA change that arises in the tumour during life. Not inherited.
Pathogenic variantA change known to be disease-causing. Here, one that raises cancer risk.
VUSVariant of uncertain significance, a change whose meaning is not yet clear.
PenetranceHow likely a carrier is to actually develop the cancer.
Cascade testingTesting blood relatives for a known family variant.
Important information and regulatory status

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Three ways forward. Pick the one that fits today.

01

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