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Heritage Core
A comprehensive hereditary-cancer panel from a simple blood or saliva sample.
01Blood or saliva sample
A broad inherited-risk assessment
Heritage Core reads the well-established genes linked to inherited cancer risk: the genes behind hereditary breast, ovarian, colorectal and other cancer syndromes.
High and moderate risk genes
Across the major hereditary syndromes, including BRCA1, BRCA2 and the Lynch syndrome mismatch-repair genes.
Clear classification
Pathogenic and likely-pathogenic variants, kept separate from variants of uncertain significance.
Actionable findings
Results that can shape your treatment, your screening and your family’s options.
02
What you receive
- A clear report of any inherited risk.
- KPCIRC genetic counselling to interpret it.
- A screening and prevention plan where relevant.
- A cascade-testing pathway so relatives can be checked with Heritage Adhoc.
Being clear about our limits
What we do and do not do
What we DO
- Assess inherited cancer risk for you
- Enable cascade testing to protect blood relatives
- Include KPCIRC genetic counselling before and after
- Flag inherited changes that can shape treatment
What we DON’T do
- Diagnose cancer or read the tumour
- Predict with certainty that a cancer will occur
- Test relatives without their own consent and counselling
- Replace clinical screening or specialist follow-up
Plain-language glossary (6 terms)
| Term | What it means |
|---|---|
| Germline | An inherited change, present from birth and passable to children. |
| Somatic | A change that arises in the tumour during life. Not inherited. |
| Pathogenic variant | A change known to be disease-causing. Here, one that raises cancer risk. |
| VUS | Variant of uncertain significance, a change whose meaning is not yet clear. |
| Penetrance | How likely a carrier is to actually develop the cancer. |
| Cascade testing | Testing blood relatives for a known family variant. |
Important information and regulatory status
Heritage Core is a genomic (DNA-based) test for use by qualified healthcare professionals. It supports clinical judgement, it does not replace it, and it must be read alongside your full clinical history and applicable guidelines.
- A result is not a diagnosis and does not by itself decide treatment.
- A “not detected” result does not rule out cancer or a genetic change.
- Not all cancers release enough DNA into blood to be detected.
- We cannot guarantee that a medicine will be available, approved, covered or effective.
- Collection kits are for qualified phlebotomists. They are not for self-testing.
- Confirmatory testing may be required.
Regulatory status (India). Registration of our genomic tests as in-vitro diagnostic (IVD) medical devices with CDSCO is in progress, with the IVD class pending. Sequencing and variant calling are done by an accredited laboratory partner (CAP-accredited, ISO 15189) following ACMG/AMP/ASCO/CAP guidelines and a CE-IVD certified variant database. The OnKommon interpretation engine is provided for research and decision-support use. Marketing follows the Drugs and Magic Remedies (Objectionable Advertisements) Act, 1954.
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