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Finished treatmentWatching for anything left behindWorried about familyInherited risk, and relativesWanting a second opinionA decision you are unsure aboutDecide
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Six situations. Find the one that sounds like yours, and we will tell you what usually happens next, what it costs, and what people most often get wrong there.
Every route includes something free, because the first question should not have a price on it.
01How this page works
Tell us where you are. We will tell you what usually happens next.
Most cancer websites are organised around what the company sells. That works for the company and not for anyone arriving at eleven at night with a report they cannot read. So this page is organised the other way round: six situations, what is usually true in each, where to go next, and the mistake people most often make there.
Every route below includes at least one thing that costs nothing, because the first question should not have a price on it.
The evening the reports arrive
The moment this page exists for: someone at a kitchen table at night with a folder of reports they cannot read, phone in hand. Not despairing, just stuck. Every visitor who needs this page has had this evening.
Wide, low warm light, from across the table. Subject slightly off centre with space for the headline. Shoot late, genuinely, not day-for-night.
Must be in frame
Must not be
“There are reports arriving and appointments booked, and I still do not understand what is actually being decided.”
What is usually true at this point
At this point the diagnosis, the stage and the histology are usually established, and the treatment discussion is about to begin. This is the moment where molecular information is most likely to change the first treatment given rather than the second, which is why the timing of any testing matters as much as the testing itself.
The common mistake. Ordering the broadest possible test because it sounds thorough. The right test is the one that answers the question in front of you, and a bigger panel is not automatically a better one.
Where to go next
Ask one free question firstSignal replies on WhatsApp within four hours. Use it to find out whether testing is even the right question for your situation before spending anything.OpenRead your cancer’s dictionary entryIt tells you what is commonly discussed in your specific cancer, and gives you questions to take to your treating team.OpenBook a free consultationA no-obligation conversation about whether any of this applies to you, and which tier fits the question you actually have.Open“I have a genomic report. I can see a list of gene names. Nobody has told me what to do with it.”
What is usually true at this point
A variant list is not a decision. Sequencing produces the raw material; interpretation turns it into ranked options with evidence attached. If sequencing has already been done properly, repeating it usually adds cost and delay rather than information.
The common mistake. Assuming the earlier test covered everything. The most common gap is a panel that read point mutations but not fusions or copy number, which can miss findings that are directly actionable.
Where to go next
Start with DecipherFull interpretation and tumour board sign-out on data generated elsewhere. No resequencing, no new sample.OpenOr Decipher Plus, if there are gapsWhere the original panel missed something material, we top up only the gap rather than starting again.OpenBring your records together firstNavigation turns the records you already have into a clarity timeline, which is often the fastest way to see what is actually missing.Open“We started something. I do not know whether it is working, and I find out every few months when there is a scan.”
What is usually true at this point
Scans show what has already happened to the size of a tumour. Molecular monitoring asks a different question, and can register change earlier. Whether that earlier signal should change what you do is a clinical judgement, and one worth having explicitly before you start monitoring rather than after a result arrives.
The common mistake. Starting monitoring without agreeing in advance what a positive result would mean. Information you cannot act on can be harder to live with than not knowing.
Where to go next
Understand SentinelSerial monitoring during active treatment: is it working, and is resistance emerging. A subscription of two, four or six draws a year.OpenAsk what would changeBefore starting monitoring, it is worth asking your team what a rising or falling result would actually cause them to do.OpenRead about resistance in your cancerEvery dictionary entry has a section on the questions worth raising at progression.Open“They said it went well. Now I am just waiting, and every appointment feels like an exam I did not study for.”
What is usually true at this point
After treatment given with curative intent, the question is whether anything remains below what a scan can see. Molecular residual disease testing is the most active research area in oncology surveillance, and it is genuinely more established in some cancers than others. We will tell you which yours is.
The common mistake. Treating surveillance as reassurance. Its value is in acting earlier where acting earlier helps, and in several cancers whether it helps is still being tested.
Where to go next
Understand ClearMolecular residual disease surveillance after curative-intent treatment, on a schedule matched to your cancer and follow-up plan.OpenCheck where the evidence stands in your cancerThe ctDNA section of each dictionary entry says whether this is established practice or an active research question in that disease.OpenAsk us honestlyIn some cancers we will tell you that the evidence does not yet support it. That is a real answer, and it costs nothing to get.Open“My mother had it, and her sister. I want to know whether my children need to worry.”
What is usually true at this point
Inherited risk is a different test from tumour profiling, on a different sample, answering a different question. A tumour panel reporting a BRCA alteration does not by itself establish that it is inherited. Where an inherited alteration is confirmed, relatives can often act on the information long before any cancer develops, which is the part that matters most.
The common mistake. Testing relatives before the alteration in the family is identified. Testing a healthy relative without knowing what to look for is far less informative than it sounds, and a negative result can be falsely reassuring.
Where to go next
Start with HeritageA proper inherited-risk assessment, with genetic counselling built in rather than bolted on.OpenThen Heritage Adhoc for relativesOnce a family alteration is known, testing relatives is focused and costs less, because we are looking for one specific thing.OpenRead the germline section for your family’s cancerSeveral cancers raise the inherited-risk question routinely rather than only when there is a family history. Your entry will say which.Open“I have been given a plan. I do not doubt my doctor, but I want to know that everything was considered.”
What is usually true at this point
Wanting a second opinion is not a criticism of anyone. In complex cases, a molecular tumour board exists precisely because no single clinician is expected to hold every detail of a fast-moving field. Your treating oncologist remains in charge throughout.
The common mistake. Waiting until a decision has already been made and acted on. A second opinion is most useful before the decision, not after it.
Where to go next
Request a KPCIRC second opinionThe same licensed clinicians who sign our reports, available directly. Paid, and arranged through our clinical partner.OpenOr start with a free questionIf you are not sure a formal second opinion is what you need, ask first. We will say so if it is not.OpenBring the paperwork with youA second opinion is only as good as what it is given. Navigation assembles your records into something a board can read quickly.Open02The seventh situation
Plenty of situations do not fit six boxes: a rare cancer, a diagnosis that keeps changing, a relative you are caring for, a decision made years ago that you are only now questioning. Ask us anyway. Signal is free, answered by a person within four hours, and we will tell you honestly if we are not the right people.
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